BIPOLAR DISORDER OUTLINE Article Example | Topics and Well Written Essays - 750 words

BIPOLAR DISORDER OUTLINE - Article ExampleCause of bipolar distemper is not known but genetic and environmental conditions may give rise to the disorder and its course. environmental factors may include substance abuse, medical conditions (e.g. thyroid fluctuation), stressful lie events, and life styles that are agreeable with general sleep-wake cycles. PET imaging helps identify differences in brain activities of the people with the disorder. This and other biological researches withdraw rendered better understanding of the causes of the disorder such as dys formula (not like an epileptic seizure) of the brain cells responsible for regulation of emotions, circadian rhythms and behaviors resulting in the symptoms of the disorder (Goodwin & Jamison, 2007). Bipolar disorder now ranks one of the top ten disable disorders in the world among working adults with signifi toilett socio economic impact (WHO, 2002), (Young, Rigney, Shaw, Emmas, & Thompson, 2011). Bipolar experience of the illness can vary among patients substantially. Such as, some patients with low followed by hypomania while others, mania followed by depression. Still others with jump possibilitys with no intervals of mood stability (euthymia). Choice of interpositions therefore is based on individualistic patterns of the disorder (Suppes & Dennehy, 2012). Guidelines of the homo Federation of Societies of Biological Psychiatry (WFSBP) for the biological treatment of bipolar disorders mainly deal with the acute treatment of mania and bipolar depression. It is vital that acute and long-term treatment should be simultaneous for treatment mean and evaluation. For simplicity, both are dealt with separately. It is important to bring the acute manifestations under control as quick as possible but it is more important to devote maintenance treatment which should prevent new episodes and complications and disqualifying conditions (Grunz, et al., 2013). See figure below Grunz et al (2013)s overall re commendations for long term treatment have assigned Rating Grade (RG) 1 to drugs Aripiprazole, Lamotrigine, Lithium, and Quetiapine which are listed alphabetically. Aripiprazole has been graded A for Prevention of Treatment sudden Episodes (TEE) in enriched samples ( human foot) for mania and any episode. Lamotrigine, has been rated A in pes for depression and any episode. Lithium, A in PNES (Prevention of TEE in non-enriched samples) for mania and any episode and B in PES for any episode, mania and depression. Quetiapine, graded A in PES for mania, depression and any episode. The authors overall rating goes in favor of Lithium as still the topper as it has two grading of A and B for episodes mentioned against each (Grunz, et al., 2013, p. 170). These drugs treatments are discussed in detail below. ARIPIPRAZOLE PES Monothreapy and combination with Lithium have proved to be efficacious in the prevention of new frenetic and mixed episodes in acute mania. PNES As there is no long-te rm impact study in non-enriched samples, it has been graded F in respect of CE (Category of evidence). Further evidence (FE) of the efficacy of Aripiprazole has been proved in the metaanalysis by Vieta et al (2011) in the prevention of new manic episodes. Safety and tolerability (ST) Most common indecent event (AE) prompting treatment